NanoSyrinx is built around an entirely genetically encoded drug delivery system, making use of naturally occurring ‘nanosyringes’. By engineering the upstream genetics, an entire drug delivery vehicle can be produced – loaded and ready for use – using a simple bacterial fermentation step. No clumsy conjugations, no optimisation of conditions; a simple bacterial fermentation process yielding ready-to-go material. It’s as simple as that.
NanoSyrinx’s proprietary platform utilises a core suite of genes, encoding the syringe ‘chassis’, the biological payloads and cell targeting domains which, when expressed, self-assemble in a single step to produce fully formed nanosyringes.
Nanosyringes can be engineered to deliver a wide range of protein and peptide payloads – representing a diverse array of biological functions – in a targeted way. We are developing the technology as a completely new therapeutic modality, opening up an entirely new range of intracellular targets and enabling the development of safe and effective treatments addressing a wide range of medical unmet needs.